Columnar and layer-specific representation of spatial sensitivity in mouse primary auditory cortex.

The primary auditory cortex (AI) is implicated in coding sound location, as revealed by behavior-lesion experiments, but our knowledge about the functional organization and laminar specificity of neural spatial sensitivity is still very limited. Using single-unit recordings in mouse AI, we show that (i) an inverse relationship between onset latency and spike count is consistently observed when all the azimuthal points are taken; (ii) a substantial proportion of penetrations perpendicular to the AI surface showed columnar organization of best azimuths; (iii) the preferred azimuth range of AI neurons demonstrated layer-specific distribution pattern. Our findings suggest that similar to other response properties, the manner of sound space information processing in the auditory cortex is also layer dependent.